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Vitamin D and vitamin K have diverse and complementary physiological functions, close associations with age-related and chronic diseases, and a strong body of clinical evidence documenting widespread insufficiency and therapeutic potential.1, 2 Vitamin D has both hormonal and non-hormonal functions, with vitamin D receptors translating into a myriad of physiological actions, ranging from bone metabolism to modulation of immune activity.
Vitamin D regulates the expression of hundreds of genes, influences cellular proliferation and signaling, insulin production and sensitivity, and is a critical inhibitor of several inflammatory pathways.5, 6
Vitamin K-dependent (VKD) proteins also have a nearly ubiquitous presence and regulate diverse functions including cellular growth, arterial calcification and bone metabolism.12 Vitamins K and D have complementary physiological functions, and clinical trials have shown synergistic benefit for both osteoporosis and cardiovascular disease when used together.
•Provides clinically effective doses of vitamins D and K per softgel
•Vitamin D3 has the highest potency for increasing serum and storage levels of vitamin D
•Uses the optimal form of vitamin K, vitamin K2 Menaquinone-7 (MK-7)
•MK-7 has the longest half-life and best extra-hepatic distribution of all forms
•A D3 and MK-7 combination has a synergistic benefit compared to single nutrient therapy
Take 1 softgel per day or as directed by a health care professional.
Serving Size: 1 Softgel
Amount Per Serving
Vitamin D3 … 1000IU
(Cholecalciferol)
Vitamin K2 … 120mcg
(Menaquinone-7)(MK-7)(natto bean)
Other ingredients: Softgel (gelatin, glycerin, purified water, caramel, titanium dioxide), medium chain triglycerides (coconut), beeswax, soy lecithin.
Consult a health care professional prior to use if you are taking blood thinners. Patients with chronic kidney or liver disease, sarcoidosis, lymphoma, tuberculosis, hypercalcemia, or those undergoing hemodialysis should only use under medical supervision. Keep out of reach of children.
When taken with a thiazide medication (diuretic), vitamin D may increase the risk for hypercalcemia. Also, vitamin D may improve insulin sensitivity and lower blood pressure, requiring a reduction in dosage of hypertension and/or diabetic medications. Vitamin K may antagonize the effect of some anticoagulant medications, particularly warfarin, and should be taken together only with medical supervision. Recent data suggests vitamin K supplementation may stabilize INR’s and reduce adverse effects among those on vitamin K antagonists, but combined use should be carefully monitored.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Â
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